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Brock Purdy
Brock Purdy Officially limited in return to practice
Wed, Sep 17, 2025, 6:42 PM
Purdy (left shoulder/toe) officially was a limited practice participant Wednesday, Matt Barrows of The Athletic reports.
Analysis: Purdy fulfilled coach Kyle Shanahan's expectation for his activity level from earlier Wednesday, per Eric Branch of the San Francisco Chronicle. During the media-access portion of the session, Purdy was third in the QB rotation behind Mac Jones and Adrian Martinez, according to Cam Inman of The San Jose Mercury News, and he was seen making throws and also jogging on what has been described as a turf toe variant, per Branch. Purdy thus seemingly has a chance to return to action Sunday versus the Cardinals, but how he fares Thursday and Friday will be telling for his Week 3 availability. Mac Jones will continue to start as long as Purdy is sidelined.
Jauan Jennings
Jauan Jennings No practice Wednesday
Wed, Sep 17, 2025, 6:32 PM
Jennings (ankle/shoulder) officially didn't practice Wednesday, Matt Barrows of The Athletic reports.
Analysis: During Week 2 prep, Jennings missed the first two practices before logging a limited session Friday as he tended to a shoulder injury, but it was enough for him to suit up this past Sunday at New Orleans and serve as the 49ers' top wide receiver for fill-in quarterback Mac Jones. On his 10 targets, Jennings hauled in five receptions for 89 yards and one touchdown. Coach Kyle Shanahan termed Jennings day-to-day Monday due to an ankle injury, and with another DNP under his belt to begin this week, it remains to be seen if he'll follow a similar practice regimen to last week and how he'll be listed ahead of Sunday's home opener against the Cardinals.
Brandon Aiyuk
Brandon Aiyuk Spotted running
Wed, Sep 17, 2025, 5:06 PM
Aiyuk (knee) did some running while his teammates were practicing Wednesday, Nick Wagoner of ESPN.com reports.
Analysis: Aiyuk remains on the PUP list, out through at least Week 4 and unable to practice with his teammates. Neither player nor team has said much about the situation of late, but coach Kyle Shanahan did suggest in mid-August that Week 6 (against Tampa Bay) was a reasonable target for Aiyuk's 2025 debut.
Brayden Willis
Brayden Willis Bumps to active roster
Wed, Sep 17, 2025, 3:15 PM
The 49ers signed Willis to the active roster from the practice squad Wednesday.
Analysis: Willis takes the roster spot of Ben Bartch, who San Francisco placed on IR on Wednesday. With George Kittle (hamstring) also on IR until at least Week 6, Willis is positioned to contribute in a reserve role at tight end versus the Cardinals on Sunday, and beyond.
Jauan Jennings
Jauan Jennings Limited Wednesday
Wed, Sep 17, 2025, 3:12 PM
Jennings (shoulder/ankle) will be limited at practice Wednesday, Cam Inman of The San Jose Mercury News reports.
Analysis: Jennings exited a season-opening win at Seattle due to a left shoulder injury that capped him to one limited session during Week 2 prep. He was able to suit up this past Sunday in New Orleans and take on an 87 percent snap share on his way to five catches (on 10 targets) for 89 yards and one touchdown while working with fill-in starting quarterback Mac Jones. Jennings will be joined as a limited participant Wednesday by No. 1 signal-caller Brock Purdy (toe/left shoulder), who has a chance to return to action this Sunday versus the Cardinals, as coach Kyle Shanahan told Nick Wagoner of ESPN.com on Wednesday. As a result, the potential exists for Jennings to have his most familiar quarterback under center Week 3, assuming the wide receiver is able to play through his shoulder and ankle issues.
Brock Purdy
Brock Purdy In line for limited practice
Wed, Sep 17, 2025, 3:03 PM
Coach Kyle Shanahan said Purdy (toe/shoulder) will be limited at Wednesday's practice, Eric Branch of the San Francisco Chronicle reports.
Analysis: Purdy emerged from a Week 1 win at Seattle with a turf toe variant, which sidelined him this past Sunday in New Orleans. As the 49ers begin preparations for Sunday's home opener against the Cardinals, Shanahan is giving Purdy "a chance" to return to action, even as the emergency third quarterback, per Nick Wagoner of ESPN.com. As a result, it appears Purdy and fill-in Week 2 starter Mac Jones are in consideration to lead San Francisco's offense Week 3.
Jauan Jennings
Jauan Jennings Day-to-day with ankle issue
Mon, Sep 15, 2025, 5:19 PM
Coach Kyle Shanahan noted Monday that Jennings came out of Week 2 action with an ankle injury, Jennifer Lee Chan of NBC Sports Bay Area reports.
Analysis: Per Nick Wagoner of ESPN.com, Jennings is viewed as day-to-day as this weekend's game against the Cardinals approaches. In Sunday's 26-21 win over the Saints, Jennings parlayed his 87 percent snap share into 5-89-1 line on a team-high 10 targets.
Marquez Valdes-Scantling
Marquez Valdes-Scantling Logs nine snaps on offense
Mon, Sep 15, 2025, 1:50 PM
Valdes-Scantling failed to bring in his only target in Sunday's 26-21 win over the Saints.
Analysis: Valdes-Scantling was a non-factor on offense for the second consecutive week. The veteran wideout saw his snap count drop to nine (13 percent) following the addition of WR Kendrick Bourne (49 percent). Valdes-Scantling carries no fantasy value heading into a Week 3 matchup against the Cardinals.
Jake Tonges
Jake Tonges Nabs four receptions Sunday
Mon, Sep 15, 2025, 1:37 PM
Tonges finished with four receptions (on five targets) for 31 yards in Sunday's 26-21 win over the Saints.
Analysis: Luke Farrell got the start in place of George Kittle (hamstring), but Tonges finished the contest with more snaps played (56 to 41) and targets (five to three). The former cashed in a short touchdown grab to produce the superior fantasy total after Tonges took those honors last week. It appears that both tight ends will help fill Kittle's shoes while the superstar is sidelined for multiple weeks. The timeshare puts a hard cap on Tonges' fantasy potential, limiting his Week 3 value to those in deeper formats.
Luke Farrell
Luke Farrell Scores first TD of career
Mon, Sep 15, 2025, 1:30 PM
Farrell brought in two of three targets for 15 yards and a touchdown in Sunday's 26-21 win over the Saints.
Analysis: Farrell got the start in place of George Kittle (hamstring) on Sunday, finishing with 41 snaps played on offense (58 percent). Jake Tonges wound up playing more snaps (79 percent) while garnering more targets (five) in the passing game, but it was Farrell who cashed in one of Mac Jones's three touchdown passes. It appears that the 49ers will deploy both tight ends in tandem while Kittle mends on injured reserve. In that scenario, neither option offers much fantasy upside heading into next Sunday's tilt against Arizona.
Isaac Guerendo
Isaac Guerendo No carries in Week 2 win
Mon, Sep 15, 2025, 1:18 PM
Guerendo returned two kickoffs for 47 yards and was not used on offense in Sunday's 26-21 win over the Saints.
Analysis: Guerendo failed to see the field on offense Sunday, logging all 17 of his snaps on special teams. Veteran backup Brian Robinson continues to handle all of the touches starter Christian McCaffrey doesn't gobble up on game days. More of the same can be expected against the Cardinals in Week 3, leaving Guerendo off the fantasy radar until an injury opens up playing time for the sophomore.
Brian Robinson
Brian Robinson Handles seven touches Sunday
Mon, Sep 15, 2025, 1:10 PM
Robinson rushed six times for 20 yards and caught his only target for a loss of one yard in Sunday's 26-21 win over New Orleans.
Analysis: Robinson struggled to find much running room with his allotted touches Sunday. The 26-year-old wound up playing 16 snaps on offense (23 percent) and was still the only backup runner deployed behind Christian McCaffrey. Robinson will continue serving a change-of-pace role for the 49ers against the Cardinals next Sunday.
Kendrick Bourne
Kendrick Bourne Three catches in return to Niners
Sun, Sep 14, 2025, 4:36 PM
Bourne caught all three of his targets for 32 yards in Sunday's 26-21 win over the Saints.
Analysis: Seeing his first action as a 49er since 2020 after four seasons with the Patriots, Bourne wound up catching passes from a familiar face in former New England quarterback Mac Jones, who was filling in for Brock Purdy (toe/shoulder). Bourne's longest gain went for 13 yards, and as expected, he operated as the clear No. 3 wide receiver behind Jauan Jennings and Ricky Pearsall. Bourne could get competition for that role as soon as Week 4, when Demarcus Robinson returns from a suspension, but that still gives him at least one more game, Week 3 against the Cardinals, in which to make an impact in Week 3.
Ricky Pearsall
Ricky Pearsall Four grabs in Week 2 win
Sun, Sep 14, 2025, 4:30 PM
Pearsall caught four of six targets for 56 yards in Sunday's 26-21 win over the Saints. He also rushed once for minus-4 yards.
Analysis: The second-year wideout couldn't repeat his big Week 1 performance with Mac Jones under center instead of Brock Purdy (toe/shoulder), but Pearsall still delivered solid production while finishing third on the 49ers in volume behind Jauan Jennings (10 targets) and Christian McCaffrey (seven). Purdy is expected to miss multiple weeks, but Pearsall's involvement in the passing game Sunday suggests there's little reason to downgrade his outlook while catching passes from Jones. Pearsall could be busy again in Week 3 against the Cardinals.
Jauan Jennings
Jauan Jennings Hauls in deep TD against Saints
Sun, Sep 14, 2025, 4:23 PM
Jennings caught five of 10 targets for 89 yards and a touchdown in Sunday's 26-21 win over New Orleans.
Analysis: The veteran wideout had a little trouble getting on the same page with new quarterback Mac Jones early in the contest, but the duo connected on a 42-yard TD in the fourth quarter that proved to be the game-winning score. Jennings' final line, and the performance of the 49ers' offense in general without Brock Purdy (toe/shoulder) under center, was very encouraging, and he'll look to keep rolling in a Week 3 clash with the Cardinals.
Mac Jones
Mac Jones Tosses three TDs in win
Sun, Sep 14, 2025, 4:16 PM
Jones completed 26 of 39 passes for 279 yards and three touchdowns in Sunday's 26-21 win over the Saints. He added six rushing yards on six carries.
Analysis: The three passing TDs tied the former Patriot's career high, as Jones connected with Luke Farrell in the first quarter, Christian McCaffrey in the second and Jauan Jennings in the fourth. With Brock Purdy (toe/shoulder) expected to miss multiple games, Jones could get a chance to grow comfortable at the helm of the 49ers' offense, although he'll be without the services of George Kittle (hamstring) and Brandon Aiyuk (knee). Assuming Purdy doesn't make a rapid recovery, Jones will look to carry his momentum into a Week 3 matchup against the Cardinals.
Christian McCaffrey
Christian McCaffrey Finds end zone in Week 2 win
Sun, Sep 14, 2025, 4:06 PM
McCaffrey carried the ball 13 times for 55 yards and caught six of seven targets for 52 yards and a touchdown in Sunday's 26-21 win over the Saints.
Analysis: With the 49ers' offense missing a number of key players, including Brock Purdy (toe/shoulder), George Kittle (hamstring) and Brandon Aiyuk (knee), McCaffrey put the team on his back and carried it to a second straight victory to begin the season. His seven-yard TD reception from Mac Jones just before halftime was McCaffrey's first score of the year, but he's topped 100 scrimmage yards in both of the Niners' games so far. In Week 3, he'll take aim at a Cardinals defense he didn't face during an injury-plagued 2024, but which he lit up for an incredible 364 combined yards and seven total touchdowns in their two 2023 meetings.
Kyle Juszczyk
Kyle Juszczyk Won't return vs. New Orleans
Sun, Sep 14, 2025, 1:04 PM
Juszczyk has been ruled out for the rest of Sunday's game against the Saints due to a concussion, Jennifer Lee Chan of NBC Sports Bay Area reports.
Analysis: Juszczyk was evaluated on the sidelines after taking a hit to the head in the first half of Sunday's game, and the veteran fullback has been diagnosed with a concussion. He will not be allowed to return to Sunday's game, and he'll have to pass the league's five-step concussion protocol in order to play in Week 3 against the Cardinals on Sunday, Sept. 21. Juszczyk is the only fullback on the 49ers' active roster, but tight ends Luke Farrell, Jake Tonges or Brayden Willis could be deployed as a backfield blocker for the rest of Sunday's contest.
Jordan James
Jordan James Healthy scratch vs. NOLA
Sun, Sep 14, 2025, 11:12 AM
James (coach's decision) is inactive for Sunday's game against the Saints, Briana Jeannel of the 49ers' official site reports.
Analysis: The rookie fifth-rounder broke his finger in early August and was not cleared to play against the Seahawks in Week 1. James was able to fade an injury designation ahead of Sunday's game after logging a full practice Friday, but he'll observe the contest in street clothes while the 49ers roll with a three-man backfield of Brian Robinson, Isaac Guerendo and starter Christian McCaffrey. James' next chance to make his NFL regular-season debut is Week 3 against the Cardinals on Sunday, Sept. 21.
Jordan Watkins
Jordan Watkins Pro debut pushed back
Sun, Sep 14, 2025, 10:55 AM
Watkins (coach's decision) is inactive for Sunday's game at New Orleans, Briana Jeannel of the 49ers' official site reports.
Analysis: Watkins didn't suit up Week 1 due to a lingering high-ankle sprain, but after capping Week 2 prep with a full practice Friday, the rookie fourth-round pick was cleared ahead of Sunday's contest. However, he'll be a healthy scratch while Jauan Jennings (shoulder), Ricky Pearsall, Kendrick Bourne, Marquez Valdes-Scantling and Skyy Moore handle WR snaps. Watkins' next chance to make his pro debut is Sunday, Sept. 21 against the Cardinals.

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