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James Cook James Cook Set for Week 2 action Fri, Sep 12, 2025, 1:45 PM Cook (hamstring) doesn't have a designation for Sunday's contest at the Jets. Analysis: Cook was limited at Wednesday's practice due to a hamstring issue, but a full walkthrough Thursday and uncapped session Friday has cleared him to handle his typical role as the Bills' No. 1 running back. In a season-opening win against the Ravens, he earned 56 percent of the offensive snaps and turned 18 touches into 102 yards from scrimmage and one rushing TD, while reserve RBs Ray Davis and Ty Johnson combined for four touches for 25 total yards.
Dawson Knox Dawson Knox Clear for Week 2 Fri, Sep 12, 2025, 1:32 PM Knox (hip) doesn't have a designation for Sunday's game at the Jets. Analysis: The Bills limited Knox's activity level at Wednesday's practice and Thursday's walkthrough due to a hip injury, but a return to all activity Friday sets him up to be available for a Week 2 AFC East matchup. Knox earned a 57 percent snap share during this past Sunday's win against the Ravens on his way to a 2-20-0 line on two targets, while fellow TE Dalton Kincaid played 50 percent of the offensive snaps and hauled in all four of his targets for 48 yards and one touchdown.
Dawson Knox Dawson Knox Listed as limited again Thu, Sep 11, 2025, 12:35 PM Knox (hip) is listed as limited on Thursday's injury report. Analysis: The Bills only hosted a walk-thru practice Thursday, but Knox is being listed as limited for a second consecutive session. If he's unable to upgrade to full participation Friday, Knox will likely carry an injury designation into Sunday's matchup against the Jets.
James Cook James Cook Full participant Thursday Thu, Sep 11, 2025, 12:33 PM Cook (hamstring) was listed as a full participant in Thursday's walk-through. Analysis: Cook was limited by a hamstring injury Wednesday, but Thursday's full participation listing suggests he isn't in any danger of sitting out against the Jets in Week 2. In the Bills' season-opening win over Baltimore, Cook turned 18 touches into 102 scrimmage yards and a touchdown while Ray Davis and Ty Johnson combined for 25 yards on four touches.
James Cook James Cook Logs limited practice Wed, Sep 10, 2025, 2:34 PM Cook (hamstring) was listed as limited in Wednesday's practice. Analysis: In the Bills' 41-40 win over the Ravens in Week 1, Cook logged 48 of a possible 85 snaps on offense en route to carrying 13 times for 44 yards and a TD while catching all five of his targets for 58 yards. It's unclear if his hamstring issue stems from Buffalo's season opener or is the result of something that occurred Wednesday. Either way, Cook -- who is backed up by Ray Davis and Ty Johnson -- has two more chances to work fully ahead of Sunday's contest against the Jets.
Dawson Knox Dawson Knox Limited in practice Wednesday Wed, Sep 10, 2025, 2:30 PM Knox (hip) was limited in Wednesday's practice. Analysis: Knox played 57 percent of offensive snaps during Buffalo's 41-40 win over the Ravens in Week 1, securing both of his targets for 20 yards. He ran just 17 routes, though, while starting tight end Dalton Kincaid ran 28 routes and brought in all of his targets for a 4-48-1 receiving line. Knox will figure to handle a similar complementary role behind Kincaid if he's able to gain clearance in time for Sunday's road matchup against the Jets.
Ty Johnson Ty Johnson Handles two carries in opener Wed, Sep 10, 2025, 8:30 AM Johnson rushed twice for 24 yards and failed to secure either of his two targets in Sunday's 41-40 win over the Ravens. Analysis: Johnson's minimal production came on a day in which he handled 28 of the Bills' 85 offensive snaps, the second-most snaps at running back behind starter James Cook (48) and ahead of Ray Davis (10). The 27-year-old could have some good days on the stat sheet as a rotational player on one of the league's best offenses, but his limited usage will make those performances both inconsistent and hard to predict. Barring injury, Cook is the fantasy star in Buffalo's backfield, with both Johnson and Davis holding value as insurance policies. Johnson and the Bills are set to square off against the Jets in Week 2.
Elijah Moore Elijah Moore Minimal production against Ravens Wed, Sep 10, 2025, 7:59 AM Moore caught his lone target for three yards in Sunday's 41-40 win over the Ravens. Analysis: Moore was not a significant part of the Bills' offensive game plan in Week 1. The veteran played just 12 offensive snaps in the contest, the fewest of any wideout who saw action Sunday. Currently sitting at fourth on the wide receiver depth chart behind Keon Coleman, Khalil Shakir and Joshua Palmer, Moore faces an uphill battle for playing time this season. The 25-year-old should remain off the fantasy radar heading into a Week 2 matchup against the Jets.
Joshua Palmer Joshua Palmer Records five catches in win Wed, Sep 10, 2025, 7:29 AM Palmer caught five of nine targets for 61 yards in Sunday's 41-40 win over the Ravens. Analysis: Palmer played a solid 62 percent of the Bills' offensive snaps Sunday while operating as Buffalo's No. 3 wide receiver behind Keon Coleman and Khalil Shakir, who finished with snap percentages of 88 and 75 percent, respectively. Additionally, the veteran wideout's nine targets were tied for the second-highest total among all Bills pass catchers. Though he may be an inconsistent producer based on his role in an offense flush with playmakers, Palmer proved that he is a trusted target of Josh Allen in his regular season debut with Buffalo. Palmer will look to build upon his performance when the Bills visit the Jets in Week 2.
Dawson Knox Dawson Knox Two catches against Ravens Wed, Sep 10, 2025, 7:11 AM Knox caught both of his targets for 20 yards in Sunday's 41-40 win over the Ravens. Analysis: Knox led all Bills tight ends in offensive snaps, but, as expected, it was teammate Dalton Kincaid who played a bigger role in Buffalo's passing attack. Knox wasn't able to get much going, while Kincaid caught all four of his targets for 48 yards and a touchdown. Going forward, the veteran should expect similar usage, capping Knox's overall fantasy value. The 28-year-old should be ignored for fantasy purposes heading into a Week 2 matchup against the Jets.
Ray Davis Ray Davis Limited role in season opener Wed, Sep 10, 2025, 6:27 AM Davis rushed once for two yards and reeled in his lone target for minus-one yard in Sunday's 41-40 win over the Ravens. Analysis: Davis played just 10 of the Bills' 85 offensive snaps Sunday, behind starter James Cook (48) and Ty Johnson (28). With so many playmakers in Buffalo, the second-year running back should continue to struggle to earn meaningful touches out of the backfield barring an injury to Cook. With that said, Davis remains a high-value insurance policy for fantasy purposes. The 25-year-old will have his next opportunity to get involved when the Bills visit the Jets in Week 2.
Dalton Kincaid Dalton Kincaid Gets scoring started in wild win Sun, Sep 7, 2025, 11:08 PM Kincaid caught all four of his targets for 48 yards and a touchdown in Sunday's 41-40 win over the Ravens. Analysis: Kincaid scored a 15-yard touchdown on the opening drive but was relatively quiet the rest of the way, especially considering Josh Allen ultimately threw for 394 yards. This was nonetheless an encouraging performance from Kincaid, who had only two regular-season touchdowns apiece in the 2023 and 2024 campaigns. Dawson Knox had two catches for 20 yards and rookie fifth-round pick Jackson Hawes also had a 29-yard catch, but Kincaid clearly looks like the top receiving option among Buffalo's tight ends heading into Week 2 against the Jets.
Khalil Shakir Khalil Shakir Six catches in Week 1 win Sun, Sep 7, 2025, 11:07 PM Shakir caught six of nine targets for 64 yards in Sunday's 41-40 win over the Ravens. Analysis: Shakir showed no ill effects from the high-ankle sprain that sidelined him during training camp, as he finished second on the team in targets, catches and receiving yards behind Keon Coleman, who had 112 yards and a touchdown on 11 targets. Shakir led the Bills in all three categories last season, but the emergence of Coleman and addition of Joshua Palmer in the offseason gives Shakir more competition for attention from Josh Allen heading into a Week 2 road game against the Jets.
Keon Coleman Keon Coleman Breaks out in Week 1 win Sun, Sep 7, 2025, 11:06 PM Coleman caught eight of 11 targets for 112 yards and a touchdown in Sunday's 41-40 win over the Ravens. Analysis: Coleman caught a deflected ball for a 10-yard touchdown to make it a one-possession game in the fourth quarter. He also had two failed two-point conversions thrown his way and was brought down by the last defender with a shoestring tackle shortly before Buffalo's game-winning field goal, so Coleman had opportunities for an even more impressive line Sunday. The 2024 second-round pick struggled to create separation as a rookie, but he got his sophomore season off to a strong start, leading the team in receiving yards, catches and targets while setting new career highs in the last two categories. Coleman will look to build on this breakout performance in a tricky Week 2 matchup against Sauce Gardner and the Jets.
James Cook James Cook Tops 100 scrimmage yards with TD Sun, Sep 7, 2025, 11:03 PM Cook rushed 13 times for 44 yards and a touchdown while catching all five of his targets for 58 yards in Sunday's 41-40 win over the Ravens. Analysis: Cook heated up after a quiet first half. He scored a two-yard rushing touchdown in the third quarter and came two yards shy of tacking on a receiving touchdown in the fourth quarter, settling for a 51-yard gain on the play. Cook led the team in rushing yards and exceeded 100 scrimmage yards while Ty Johnson and Ray Davis combined for just three carries and three targets, so Cook unsurprisingly remains the clear lead back after signing a four-year, $48 million extension in August. Buffalo played catch-up throughout this win and will hope for a better defensive performance, which would allow for a more run-heavy game script, in Week 2 against the Jets.
Josh Allen Josh Allen Four total TDs in Week 1 thriller Sun, Sep 7, 2025, 11:00 PM Allen completed 33 of 46 passes for 394 yards and two touchdowns while rushing 14 times for 30 yards and two touchdowns in Sunday's 41-40 win over the Ravens. Analysis: Allen opened the scoring with a 15-yard touchdown pass to Dalton Kincaid on the opening drive, but the Ravens responded with a 20-3 run. Allen and the offense kept Buffalo within striking distance in the second half, and the dual-threat quarterback scored a two-yard rushing touchdown early in the fourth quarter, two plays after connecting with James Cook for a 51-yard gain through the air. That rushing score was the 66th of Allen's regular-season career, surpassing Thurman Thomas for the most in Bills history. Allen then tossed a 10-yard touchdown pass to Keon Coleman and added a one-yard rushing touchdown before guiding the offense in position for a game-winning field goal in the final seconds of a fourth quarter that featured 251 Allen passing yards, as the Bills played their best football down the stretch while the Ravens sputtered. With the other three AFC East teams all losing Sunday, the Bills already hold the division lead heading into a Week 2 road game against the Jets.
Curtis Samuel Curtis Samuel Inactive for Week 1 Sun, Sep 7, 2025, 5:58 PM Samuel is inactive for Sunday night's season opener against the Ravens. Analysis: Samuel wasn't listed on the Bills' Week 1 injury report, but he'll be the odd man out versus Baltimore. As a result, Khalil Shakir, Keon Coleman, Joshua Palmer, Elijah Moore and Tyrell Shavers are Buffalo's available WRs on Sunday.
Khalil Shakir Khalil Shakir Cleared after full practices Fri, Sep 5, 2025, 3:36 PM Shakir (ankle) doesn't have an injury designation for Sunday's game against the Ravens. Analysis: Shakir logged three full practices during the week, suggesting he has made a full recovery from the high-ankle sprain that sidelined him for the entire preseason. Buffalo's receiving corps will be at 100 percent Sunday, as Keon Coleman (groin) and Elijah Moore (personal) also avoided injury designations Friday. Shakir led the Bills in catches (76) and receiving yards (821) during the 2024 regular season.
Keon Coleman Keon Coleman Good to go for season opener Fri, Sep 5, 2025, 3:08 PM Coleman (groin) doesn't have an injury designation for Sunday's game against the Ravens. Analysis: Coleman was limited in practice by a groin issue Wednesday and Thursday but expressed optimism about his chances of suiting up Friday before proceeding to log a full session, which helped him avoid a Week 1 injury tag. Wide receivers Khalil Shakir (ankle) and Elijah Moore (personal) also avoided designations, so the position group will be at full strength for the regular-season opener.
Keon Coleman Keon Coleman Expects to play Fri, Sep 5, 2025, 1:15 PM Coleman (groin) said Friday that he isn't concerned about his status for Sunday's game against Baltimore, Alaina Getzenberg of ESPN.com reports. Analysis: Coleman is scheduled for limited practice participation Friday, the same as Thursday and Wednesday. He may have an injury status for the game but apparently isn't worried about missing it. Coleman, Joshua Palmer and Khalil Shakir figure to take the vast majority of snaps Sunday night, unless Coleman suffers an end-of-week setback.