Analysis: Knox put together a three-catch effort for the second time in as many postseason contests. However, his day, and that of the Bills, would have been much bigger had Josh Allen not missed him as he ran down the seam and toward the end zone on a third-down play with 16 seconds remaining in regulation and Buffalo trailing by three. Knox's solid postseason was preceded by his most productive regular season since 2022, as he posted a 36-417-4 line on 49 targets across 17 games.

Analysis: Shakir led the Bills in receptions and targets after having posted a 12-82-0 line in the wild-card win over the Jaguars. The veteran wideout also recorded a game-high 46-yard catch in an early fourth-quarter drive that culminated in a go-ahead 14-yard scoring strike to Dalton Kincaid. Shakir's highly productive postseason was preceded by a similarly busy regular season, one where he generated a 72-719-4 line on 95 targets, rushed once for five yards, lost his only fumble and recorded 124 punt-return yards across 16 games.

Analysis: The talented tight end shook off some nagging knee and calf injuries to suit up and finish as the Bills' leader in receiving yards on the afternoon. Kincaid also contributed to Buffalo's comeback from what had been a 23-10 deficit by recording a 14-yard touchdown grab early in the fourth quarter. Both Kincaid's reception and receiving yardage tallies were his highest since Week 9, while his scoring catch was his second in as many playoff games. Kincaid also put together a solid 2025 regular season during which he missed five games, generating a 39-571-5 line on 49 targets, with 13 of his catches going for 20-plus yards.

Analysis: Cook put together an impressive day on the ground against an elite defense, finishing with his 10th 100-yard performance since the start of the regular season and bouncing back in noteworthy fashion from his 46-yard effort versus the Jaguars in Sunday's wild-card victory. Cook's second-quarter lost fumble had a significant impact, however, as it came at the Broncos' 30-yard line and eventually led to a Denver touchdown. The disappointing team outcome aside, Cook's productive day Saturday was a fitting cap to a career-best regular season, one where he won the NFL rushing yardage title with 1,621 yards while averaging 5.2 yards per carry, scored 12 rushing touchdowns, and generated a 33-291-2 line on 40 targets while committing six fumbles, losing three, across 17 games.

Analysis: While Allen put together a fantasy-friendly stat line from a yardage and touchdown perspective, his four turnovers naturally had a significant hand in the narrow and heartbreaking defeat. Allen connected with Mecole Hardman (four yards), Keon Coleman (10 yards) and Dalton Kincaid (14 yards) for his trio of scoring tosses, the latter two coming during an impressive second-half surge by Buffalo that saw the Bills erase a 23-10 deficit and take a 27-23 lead with just over four minutes remaining. Following a late Broncos touchdown, Allen then led an eight-play march that culminated in a game-tying field goal that pushed the game into overtime. However, Allen's second interception, which came when Ja'Quan McMillian took the ball from Brandin Cooks as both went to the ground after the latter appeared to have hauled in a beautifully thrown deep post, begat Denver's game-winning drive, while his two earlier lost fumbles each led to Broncos field goals as well. Following another January heartbreak for his team, Allen will focus on regrouping for another run in 2026 after having completed 69.3 percent of his passes for 3,668 yards with a 25:10 TD:INT, rushing 112 times for 579 yards and 14 touchdowns and committing seven fumbles, losing three, across 17 regular-season games in 2025.

Analysis: Samuel thus will be available to Buffalo's offense for the first time since Week 11 after a lengthy IR stint, and the timing of his activation couldn't have come at a better time after all of Joshua Palmer (ankle), Tyrell Shavers (knee) and Gabe Davis (knee) landed on injured reserve in the past week. Along with Khalil Shakir, Brandin Cooks, Keon Coleman and Mecole Hardman, Samuel will be one of the options at wide receiver available to QB Josh Allen, but he muster only a 7-81-1 line on nine targets in six appearances earlier this season.

Analysis: Johnson suffered an ankle injury Week 18 against the Jets that now has sidelined him for both of Buffalo's first two playoff contests. With Johnson out again, Ray Davis and Frank Gore will be the backfield options behind starter James Cook.

Analysis: With Ty Johnson's (ankle) status in question for Saturday's divisional-round game against the Broncos, Gore will again have a chance to play behind James Cook and Ray Davis. Gore made his non-exhibition NFL debut last Sunday against the Jaguars, catching his lone target for six yards while playing four offensive snaps.

Analysis: Hardman figures to be active for Saturday's divisional-round contest against the Broncos after the team recently lost all three of Joshua Palmer (ankle), Tyrell Shavers (knee) and Gabe Davis (knee) to season-ending injuries. Hardman would likely see most of his action on special teams as a returner.

Analysis: Samuel remains listed as questionable for Saturday's divisional-round game against the Broncos, but his activation would seem to indicate Samuel will be ready to play. With Joshua Palmer (ankle) placed on injured reserve last week and both Gabe Davis (knee) and Tyrell Shavers (knee) lost to season-ending injuries last Sunday against the Jaguars, Samuel's return will be big news for the Bills. If cleared to play, Samuel will slide into the wideout mix alongside Khalil Shakir, Brandin Cooks and Keon Coleman.

Analysis: Johnson appears to be trending in the right direction ahead of Saturday's divisional-round contest in Denver, as he upgraded to limited practice Thursday after missing Buffalo's wild-card win over the Jaguars due to an ankle issue. If active, the Maryland product could play an important role on the Bills' offense, having caught 24 of 33 targets for 263 yards and two touchdowns during the regular season, particularly with Joshua Palmer (ankle), Gabe Davis (knee) and Tyrell Shavers (knee) sidelined Saturday.

Analysis: Kincaid was listed as limited on Bills practice reports Tuesday through Thursday, but he'll be available this weekend, nonetheless. With WRs Joshua Palmer (ankle), Tyrell Shavers (knee) and Gabe Davis (knee) all on IR, Kincaid figures to be busy versus Denver in the absence of any in-game setbacks. During Buffalo's wild-card win over the Jaguars this past Sunday, Kincaid logged five targets (tied for second on the team) en route to catching three passes for 28 yards and a TD.

Analysis: Following the Bills' wild-card win over the Jaguars, the QB has been managing a trio of injuries, but after being listed as a limited participant in Tuesday's walkthrough, Allen logged back-to-back full sessions, paving the way for him to start Saturday's contest. In the process, he'll be working with a banged-up wideout corps that will be minus Joshua Palmer (ankle), Tyrell Shavers (knee) and Gabe Davis (knee), who all are on IR. In that context, WRs Khalil Shakir and Brandin Cooks and TEs Dalton Kincaid and Dawson Knox figure to be Allen's top targets, with WRs Keon Coleman and Curtis Samuel (elbow, questionable) also candidates to contribute this weekend.

Analysis: The 29-year-old from Ohio State has missed the Bills' last eight games due to an elbow injury, but following a week of full practice sessions, he's got a chance to return for the divisional round. Across six appearances this season, Samuel has caught seven of nine targets for 81 yards and a touchdown while also accumulating 223 kick return yards. If Samuel is added to Buffalo's active roster in time to play Saturday, he'll likely operate as one of the team's top wideouts, as Joshua Palmer (ankle), Tyrell Shavers (knee) and Gabe Davis (knee) are all on IR.

Analysis: The 28-year-old from Maryland opened the Bills' week of practice with consecutive DNPs after missing the wild-card round win over the Jaguars. However, Johnson upgraded to limited practice Thursday, suggesting he's trending in the right direction ahead of Saturday's matchup against the Broncos. If active for the divisional round, Johnson will likely operate as the Bills' top backup running back behind James Cook.

Analysis: Shavers will miss the remainder of Buffalo's postseason run due to a torn ACL suffered during the team's wild-card round win over the Jaguars on Sunday. His injury leaves Khalil Shakir, Brandin Cooks and Keon Coleman as the only healthy options at wideout on the team's active roster, as Gabe Davis (knee) also suffered an ACL tear versus Jacksonville and was subsequentially placed on IR. Curtis Samuel (elbow) had his 21-day practice window opened Tuesday and was listed as a full participant in the team's walkthrough practice, so he could be an option to come off IR and provide added depth for Saturday's divisional-round matchup against Denver.

Analysis: Kincaid was also listed as limited in Tuesday's walk-through practice, which gives the tight end one more opportunity to work fully before the Bills assign injury designations for Saturday's divisional-round game against the Broncos. Assuming Kincaid is available for the contest, he figures to remain a focal point in a Buffalo pass-catching corps that's been thinned-out by injuries to WRs Joshua Palmer (ankle), Tyrell Shavers (knee) and Gabe Davis (knee).

Analysis: Allen emerged from the Bills' wild-card win over the Jaguars managing a trio of injuries and was deemed a limited participant in Tuesday's walk-through. The QB's return to a full session a day later, however, solidifies the notion that he'll be available for Saturday's divisional-round game at Denver and has him trending toward not being assigned an injury designation for the contest when Buffalo's final injury report is posted Thursday.

Analysis: Wednesday marks consecutive practices in which Johnson has been unable to participate, leaving his status for Saturday's divisional-round clash with the Broncos unclear. The running back missed last Sunday's playoff victory over the Jaguars due to a persistent ankle issue, and he will likely miss this Saturday's contest unless he can upgrade his practice participation in Thursday's session.

Analysis: Samuel has been sidelined for the Bills' last eight games (including Sunday's wild-card win against the Jaguars) due to an elbow injury. His full participation in his return to practice Tuesday is an encouraging sign and puts Samuel on track to being activated from injured reserve ahead of Saturday's AFC divisional-round game against the Broncos. The return would be timely, given that both Tyrell Shaves and Gabe Davis tore their ACLs against Jacksonville.