FOLLOW THE WORLD CHAMPIONSHIP $100K LEGACY LEAGUE See More
 San Francisco 49ers
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| Return Date | Player | Status | Prognosis | Comment |
| 10/19/2026 | Kyle Juszczyk | QUESTIONABLE | Knee | |
| 10/19/2026 | Mike Evans | QUESTIONABLE | Ribs | |
| 11/8/2026 | Demarcus Robinson | IR | Ankle | |
| 10/19/2026 | Christian Kirk | IR-R | Calf | |
| 10/11/2026 | Dante Pettis | QUESTIONABLE | Calf | |
| 10/18/2026 | KhaDarel Hodge | QUESTIONABLE | Knee | |
| 11/8/2026 | Deebo Samuel Sr. | OUT | Hamstring | |
| 2/15/2027 | Brandon Aiyuk | RESERVE-DNR | Personal | |
| 9/13/2026 | Patrick Taylor Jr. | QUESTIONABLE | Undisclosed | |
| 2/15/2027 | Jake Tonges | IR | Knee - MCL | |
| 2/15/2027 | Ricky Pearsall | IR | Knee - PCL | |
| 9/13/2026 | Tanner McLachlan | QUESTIONABLE | Undisclosed | |
| 10/19/2026 | Isaac Guerendo | PUP-R | Pectoral | |
| 11/22/2026 | De'Zhaun Stribling | IR | Ankle | |
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