 San Francisco 49ers
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|---|---|---|---|---|
| Return Date | Player | Status | Prognosis | Comment |
| 9/21/2025 | Kyle Juszczyk | QUESTIONABLE | Concussion | |
| 2/16/2025 | Tajae Sharpe | QUESTIONABLE | Undisclosed | |
| 9/28/2025 | Demarcus Robinson | RESERVE-SUS | Suspension | |
| 2/9/2026 | Trent Taylor | IR | Undisclosed | |
| 10/12/2025 | George Kittle | IR | Hamstring | |
| 2/16/2025 | Chris Thompson | QUESTIONABLE | Undisclosed | |
| 9/7/2025 | Equanimeous St. Brown | QUESTIONABLE | Foot | |
| 2/9/2026 | Andy Isabella | QUESTIONABLE | Ankle | |
| 9/21/2025 | Jauan Jennings | QUESTIONABLE | Ankle | |
| 10/2/2025 | Brandon Aiyuk | PUP-R | Knee - ACL + MCL | |
| 2/9/2026 | Patrick Taylor | IR | Shoulder | |
| 2/16/2025 | Jaylon Moore | QUESTIONABLE | Undisclosed | |
| 9/28/2025 | Brock Purdy | OUT | Toe | |
| 10/2/2025 | Jacob Cowing | IR | Hamstring | |
| 9/14/2025 | Carter Bradley | QUESTIONABLE | Undisclosed | |
| 9/14/2025 | Tanner Mordecai | QUESTIONABLE | Undisclosed | |
| 9/14/2025 | Corey Kiner | QUESTIONABLE | Ankle | |
| 10/2/2025 | Kurtis Rourke | NFI-R | Knee | |
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